Chemokines are chemo tactic cyto kines that control the migratory patterns and positioning
of all immune cells. Although chemokines were initially appreciated as important mediators …

Chemokines and chemokine receptors orchestrate cell migration and homing in the body.
Humans have at least 44 chemokines that are further classified into four subfamilies based …

Memory CD4+ T helper type 2 (Th2) cells drive allergic asthma, yet the mechanisms
whereby tissue-resident memory Th2 (Th2 Trm) cells and circulating memory Th2 cells …

T cell trafficking into the lung is critical for lung immunity, but the mechanisms that mediate T
cell lung homing are not well understood. Here, we show that lung dendritic cells (DCs) …

Chronic asthma is an inflammatory disease of the airway wall that leads to bronchial smooth
muscle hyperreactivity and airway obstruction, caused by inflammation, goblet cell …

The immune system's correct functioning requires a sophisticated balance between
responses to continuous microbial challenges and tolerance to harmless antigens, such as …

The main function of the immune system is to fight off potential infections, but also to
maintain its activity below a level that would trigger self-reactivity. Regulatory T cells (Tregs) …

Eosinophilic disorders encompass a large spectrum of heterogeneous diseases sharing the
presence of elevated numbers of eosinophils in blood and/or tissues. Among these …

Asthma is associated with innate and adaptive immunity mediated by immune cells. T cell or
macrophage dysfunction plays a particularly significant role in asthma pathogenesis …

Inflammatory bone resorption is a hallmark of periodontitis, and Tregs and Th2 cells are
independently associated with disease progression attenuation. In this study, we employed …