Within the last decade, the application range of aptamers in biochemistry and medicine has
expanded rapidly. More than just a replacement for antibodies, these intrinsically structured …

RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …

Telomerase is an RNA–protein complex (RNP) that extends telomeric DNA at the 3′ ends
of chromosomes using its telomerase reverse transcriptase (TERT) and integral template …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

The structural and regulatory elements in therapeutically relevant RNAs offer many
opportunities for targeting by small molecules, yet fundamental understanding of what drives …

In recent years, there has been dramatic growth in the study of RNA. RNA has gone from
being known as an intermediate in the central dogma of molecular biology to a molecule …

Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …

Bacterial riboswitches couple small-molecule ligand binding to RNA conformational
changes that widely regulate gene expression, rendering them potential targets for antibiotic …

Riboswitches are structural elements in the 5′ untranslated regions of many bacterial
messenger RNAs that regulate gene expression in response to changing metabolite …

Regulatory mRNAs elements termed riboswitches respond to elevated concentrations of
cellular metabolites by modulating expression of associated genes. Riboswitches attain their …