Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

Glycosaminoglycans (GAGs) are important complex carbohydrates that participate in many
biological processes through the regulation of their various protein partners. Biochemical …

Heparin, a sulfated polysaccharide, is a major clinical anticoagulant. It is exploited to
overcome the natural propensity for blood to clot. Surgical procedures often require …

Although interactions of proteins with glycosaminoglycans (GAGs), such as heparin and
heparan sulphate, are of great biological importance, structural requirements for protein …

Infection of cells with adeno-associated virus (AAV) type 2 (AAV-2) is mediated by binding to
heparan sulfate proteoglycan and can be competed by heparin. Mutational analysis of AAV …

Controlled, localized drug delivery is a long-standing goal of medical research, realization of
which could reduce the harmful side-effects of drugs and allow more effective treatment of …

Heparin is a major anticoagulant with activity mediated primarily through its interaction with
antithrombin (AT). Heparan sulfate (HS), structurally related to heparin, binds a wide range …

To determine the role of individual saccharide residues of a specific heparin
pentasaccharide, denoted DEFGH, in the allosteric activation of the serpin, antithrombin, we …

Chondroitin sulfate (CS) and dermatan sulfate (DS) are linear anionic polysaccharides that
are widely present on the cell surface and in the cell matrix and connective tissue. CS and …

Polysaccharide-based materials created by physical processes have received considerable
attention for biomedical applications. These structures are often made by associating …