Mutational signatures: emerging concepts, caveats and clinical applications
Whole-genome sequencing has brought the cancer genomics community into new territory.
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Thanks to the sheer power provided by the thousands of mutations present in each patient's …
Mapping the genomic diaspora of gastric cancer
Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality.
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Pioneering genomic studies, focusing largely on primary GCs, revealed driver alterations in …
Maftools: efficient and comprehensive analysis of somatic variants in cancer
Numerous large-scale genomic studies of matched tumor-normal samples have established
the somatic landscapes of most cancer types. However, the downstream analysis of data …
the somatic landscapes of most cancer types. However, the downstream analysis of data …
Oesophageal cancer
EC Smyth, J Lagergren, RC Fitzgerald… - Nature reviews Disease …, 2017 - nature.com
Oesophageal cancer is the sixth most common cause of cancer-related death worldwide
and is therefore a major global health challenge. The two major subtypes of oesophageal …
and is therefore a major global health challenge. The two major subtypes of oesophageal …
[HTML][HTML] Comparative molecular analysis of gastrointestinal adenocarcinomas
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
examine shared and distinguishing molecular characteristics of gastrointestinal tract …
Current status and future prospects for esophageal cancer
Simple Summary Over 500,000 individuals died due to esophageal cancer (EC) worldwide
in 2020. More than four decades of etiological research have predominantly focused on the …
in 2020. More than four decades of etiological research have predominantly focused on the …
The epidemiology of esophageal adenocarcinoma
HG Coleman, SH Xie, J Lagergren - Gastroenterology, 2018 - Elsevier
The incidence of esophageal adenocarcinoma (EAC) has increased in many Western
countries and is higher in men than women. Some risk factors for EAC have been identified …
countries and is higher in men than women. Some risk factors for EAC have been identified …
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics
Esophageal adenocarcinoma (EAC) incidence is increasing while 5-year survival rates
remain less than 15%. A lack of experimental models has hampered progress. We have …
remain less than 15%. A lack of experimental models has hampered progress. We have …
Copy number signatures and mutational processes in ovarian carcinoma
G Macintyre, TE Goranova, D De Silva, D Ennis… - Nature …, 2018 - nature.com
The genomic complexity of profound copy number aberrations has prevented effective
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …
Genetic predictors of response to systemic therapy in esophagogastric cancer
The incidence of esophagogastric cancer is rapidly rising, but only a minority of patients
derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 …
derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 …