Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

In lung cancer, enrichment of the lower airway microbiota with oral commensals commonly
occurs, and ex vivo models support that some of these bacteria can trigger host …

This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …

Sequencing the RNA in a biological sample can unlock a wealth of information, including
the identity of bacteria and viruses, the nuances of alternative splicing or the transcriptional …

The flowering plant Arabidopsis thaliana is a dicot model organism for research in many
aspects of plant biology. A comprehensive annotation of its genome paves the way for …

Respiratory failure is associated with increased mortality in COVID-19 patients. There are no
validated lower airway biomarkers to predict clinical outcome. We investigated whether …

Unlike linear RNAs terminated with 5′ caps and 3′ tails, circular RNAs are characterized
by covalently closed loop structures with neither 5′ to 3′ polarity nor polyadenylated tail …

The differences between individual cells can have profound functional consequences, in
both unicellular and multicellular organisms. Recently developed single-cell mRNA …