Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Under physiological conditions, the number and function of microglia—the resident
macrophages of the CNS—is tightly controlled by the local microenvironment. In response to …

Microglia, the resident immune cells of the central nervous system (CNS), play an important
role in CNS homeostasis during development, adulthood and ageing. Their phenotype and …

Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course
over many years, but it can cause acute clinical events, including acute coronary syndromes …

Chronic or persistent fatigue is a common, debilitating symptom of several diseases.
Persistent fatigue has been associated with low-grade inflammation in several models of …

Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has
long been suspected in the pathogenesis of atherosclerosis; however, the molecular …

Here we show that iNOS-deficient mice display enhanced classically activated M1
macrophage polarization without major effects on alternatively activated M2 macrophages …

Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent
studies suggest that dynamic programing of macrophages and monocytes may give rise to …

Atherosclerosis, a chronic inflammatory disease of the arterial wall, is among the leading
causes of morbidity and mortality worldwide. The persistence of low-grade vascular …

Alzheimer's disease (AD) is a primary cause of dementia in the middle-aged and elderly
worldwide. Animal models for AD are widely used to study the disease mechanisms as well …