Endothelial barrier function and leukocyte transmigration in atherosclerosis

TJ Sluiter, JD van Buul, S Huveneers, PHA Quax… - Biomedicines, 2021 - mdpi.com
The vascular endothelium is a highly specialized barrier that controls passage of fluids and
migration of cells from the lumen into the vessel wall. Endothelial cells assist leukocytes to …

Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence

PK Lin, GE Davis - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …

The role of hepcidin and iron homeostasis in atherosclerosis

F Wunderer, L Traeger, HH Sigurslid… - Pharmacological …, 2020 - Elsevier
Atherosclerotic cardiovascular disease is a major burden on global health and a leading
cause of death worldwide. The pathophysiology of this chronic disease is complex, involving …

Inflammation in vein graft disease

MR De Vries, PHA Quax - Frontiers in cardiovascular medicine, 2018 - frontiersin.org
Bypass surgery is one of the most frequently used strategies to revascularize tissues
downstream occlusive atherosclerotic lesions. For venous bypass surgery the great …

T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword

KH Simons, A de Jong, JW Jukema… - Nature Reviews …, 2019 - nature.com
The role of inflammation in cardiovascular disease (CVD) is now widely accepted. Immune
cells, including T cells, are influenced by inflammatory signals and contribute to the onset …

Hypoxia-inducible factor-1α: the master regulator of endothelial cell senescence in vascular aging

M Alique, E Sánchez-López, G Bodega, C Giannarelli… - Cells, 2020 - mdpi.com
Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …

Mitophagy in atherosclerosis: from mechanism to therapy

Y Zhang, J Weng, L Huan, S Sheng, F Xu - Frontiers in Immunology, 2023 - frontiersin.org
Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized
mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways …

[HTML][HTML] Plaque elasticity and intraplaque neovascularisation on carotid artery ultrasound: a comparative histological study

Y Zhang, J Cao, J Zhou, C Zhang, Q Li, S Chen… - European Journal of …, 2021 - Elsevier
Objective Plaque elasticity and intraplaque neovascularisation are strongly suggestive of
vulnerable plaque. This study aimed to investigate the relationship between intraplaque …

Optical/MRI dual-modality imaging of M1 macrophage polarization in atherosclerotic plaque with MARCO-targeted upconversion luminescence probe

Y Wang, Y Zhang, Z Wang, J Zhang, RR Qiao, M Xu… - Biomaterials, 2019 - Elsevier
Pro-inflammatory M1 macrophage is identified as a prominent component initializing the
progress of vulnerable atherosclerotic plaque. Here, we constructed anti-MARCO NaGdF 4 …

One Endothelium-Targeted Combined Nucleic Acid Delivery System for Myocardial Infarction Therapy

Y Shao, C Xu, S Zhu, J Wu, C Sun, S Huang, G Li… - ACS …, 2024 - ACS Publications
Acute myocardial infarction (MI) and ischemic heart disease are the leading causes of heart
failure and mortality. Currently, research on MI treatment is focused on angiogenic and anti …