Mechanisms of antifungal drug resistance

LE Cowen, D Sanglard… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Antifungal therapy is a central component of patient management for acute and chronic
mycoses. Yet, treatment choices are restricted because of the sparse number of antifungal …

Candida and Candidiasis—Opportunism Versus Pathogenicity: A Review of the Virulence Traits

CN Ciurea, IB Kosovski, AD Mare, F Toma… - Microorganisms, 2020 - mdpi.com
One of the most important questions in microbiology nowadays, is how apparently harmless,
commensal yeasts like Candida spp. can cause a rising number of infections. The …

A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families

VK Vyas, MI Barrasa, GR Fink - Science advances, 2015 - science.org
Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with
high mortality. The absence of facile molecular genetics has been a major impediment to …

Candida albicans, a major human fungal pathogen

J Kim, P Sudbery - The journal of microbiology, 2011 - Springer
Candida albicans is the most common human fungal pathogen (Beck-Sague and Jarvis,
1993). It is normally a harmless commensal organism. However, it is a opportunistic …

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

G Butler, MD Rasmussen, MF Lin, MAS Santos… - Nature, 2009 - nature.com
Candida species are the most common cause of opportunistic fungal infection worldwide.
Here we report the genome sequences of six Candida species and compare these and …

The Candida Genome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

MS Skrzypek, J Binkley, G Binkley… - Nucleic acids …, 2016 - academic.oup.com
Abstract The Candida Genome Database (CGD, http://www. candidagenome. org/) is a
freely available online resource that provides gene, protein and sequence information for …

The Candida pathogenic species complex

SA Turner, G Butler - Cold Spring Harbor …, 2014 - perspectivesinmedicine.cshlp.org
Candida species are the most common causes of fungal infection. Approximately 90% of
infections are caused by five species: Candida albicans, Candida glabrata, Candida …

Efflux-mediated antifungal drug resistance

RD Cannon, E Lamping, AR Holmes… - Clinical microbiology …, 2009 - Am Soc Microbiol
Fungi cause serious infections in the immunocompromised and debilitated, and the
incidence of invasive mycoses has increased significantly over the last 3 decades. Slow …

Candida albicans Cell Wall Proteins

WLJ Chaffin - Microbiology and molecular biology reviews, 2008 - Am Soc Microbiol
The Candida albicans cell wall maintains the structural integrity of the organism in addtion to
providing a physical contact interface with the environment. The major components of the …

A Phenotypic Profile of the Candida albicans Regulatory Network

OR Homann, J Dea, SM Noble, AD Johnson - PLoS genetics, 2009 - journals.plos.org
Candida albicans is a normal resident of the gastrointestinal tract and also the most
prevalent fungal pathogen of humans. It last shared a common ancestor with the model …