Evolution of the SARS‐CoV‐2 omicron variants BA. 1 to BA. 5: implications for immune escape and transmission

LB Shrestha, C Foster, W Rawlinson… - Reviews in Medical …, 2022 - Wiley Online Library
The first dominant SARS‐CoV‐2 Omicron variant BA. 1 harbours 35 mutations in its Spike
protein from the original SARS‐CoV‐2 variant that emerged late 2019. Soon after its …

Omicron variant of SARS‐CoV‐2: genomics, transmissibility, and responses to current COVID‐19 vaccines

Y Araf, F Akter, Y Tang, R Fatemi… - Journal of medical …, 2022 - Wiley Online Library
Currently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has spread
worldwide as an Omicron variant. This variant is a heavily mutated virus and designated as …

T cell responses to SARS-CoV-2 spike cross-recognize Omicron

R Keeton, MB Tincho, A Ngomti, R Baguma, N Benede… - Nature, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant (B. 1.1. 529) has multiple spike protein
mutations, that contribute to viral escape from antibody neutralization,,–and reduce vaccine …

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

M McCallum, N Czudnochowski, LE Rosen, SK Zepeda… - Science, 2022 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant of
concern evades antibody-mediated immunity that comes from vaccination or infection with …

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Y Gao, C Cai, A Grifoni, TR Müller, J Niessl… - Nature medicine, 2022 - nature.com
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron (B. 1.1. 529) variant of concern (VOC) has destabilized global efforts to control the …

[HTML][HTML] Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Z Cui, P Liu, N Wang, L Wang, K Fan, Q Zhu, K Wang… - Cell, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly
worldwide. Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid …

Emergence of SARS-CoV-2 Omicron (B. 1.1. 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic

R Khandia, S Singhal, T Alqahtani, MA Kamal… - Environmental …, 2022 - Elsevier
Since the appearance in the late of December 2019, SARS-CoV-2 is rapidly evolving and
mutating continuously, giving rise to various variants with variable degrees of infectivity and …

Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination

RK Suryawanshi, IP Chen, T Ma, AM Syed, N Brazer… - Nature, 2022 - nature.com
Abstract SARS-CoV-2 Delta and Omicron are globally relevant variants of concern. Although
individuals infected with Delta are at risk of developing severe lung disease, infection with …

Early assessment of the clinical severity of the SARS-CoV-2 omicron variant in South Africa: a data linkage study

N Wolter, W Jassat, S Walaza, R Welch, H Moultrie… - The Lancet, 2022 - thelancet.com
Summary Background The SARS-CoV-2 omicron variant of concern was identified in South
Africa in November, 2021, and was associated with an increase in COVID-19 cases. We …

Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …