The methyl group is one of the most commonly occurring carbon fragments in small‐
molecule drugs. This simplest alkyl fragment appears in more than 67% of the top‐selling …

The efficacy of drugs widely varies in individuals, and the gut microbiota plays an important
role in this variability. The commensal microbiota living in the human gut encodes several …

It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Post-transcriptional RNA modifications can be dynamic and might have functions beyond
fine-tuning the structure and function of RNA. Understanding these RNA modification …

Radical S-adenosylmethionine (SAM) enzymes use the oxidizing power of a 5′-
deoxyadenosyl 5′-radical to initiate an amazing array of transformations, usually through …

We present a comprehensive analysis of the human methyltransferasome. Primary
sequences, predicted secondary structures, and solved crystal structures of known …

The active site of nitrogenase, the M-cluster, is a metal-sulfur cluster containing a carbide at
its core. Using radiolabeling experiments, we show that this carbide originates from the …

The importance of methylthioadenosine/S‐adenosylhomocysteine (MTA/SAH) nucleosidase
in bacteria has started to be appreciated only in the past decade. A comprehensive analysis …

The success of linezolid stimulated significant efforts to discover new agents in the
oxazolidinone class. Over a dozen oxazolidinones have reached the clinic, but many were …