Pregnancy is one of the strongest inducers of immunological tolerance. Disease activity of
many autoimmune diseases including multiple sclerosis (MS) is temporarily suppressed by …

A self-tolerant immune system may be regained using ASIT where T effector cells are
repressed and/or T regulatory cells are induced. Administration of exogenous antigens has …

It is unknown if cholecalciferol is able to modify defects in regulatory T cells (Tregs) in type 1
diabetes (T1D). In this randomized, double-blind, placebo controlled trial 30 young patients …

Enteroviruses and humans have long co‐existed. Although recognized in ancient times,
poliomyelitis and type 1 diabetes (T1D) were exceptionally rare and not epidemic, due in …

Umbilical cord blood is a traditional and convenient source of cells for hematopoietic stem
cell transplantation. Thymic regulatory T cells (Tregs) are also present in cord blood, and …

Pluripotent stem cells (PSCs) have the potential to produce almost all of the cells in the
body, including regulatory T cells (Tregs). However, the exact conditions required for the …

Type 1 diabetes mellitus (T1D) is a chronic autoimmune condition in which the immune
system destroys insulin-producing pancreatic β cells. In addition to well-established …

Tr1 cell therapy is considered an emerging approach to improve transplant tolerance and
enhance allogeneic graft survival. However, it remains unclear how Tr1 cells promote …

T-regulatory cells (Tregs) play a fundamental role in the creation and maintenance of
peripheral tolerance. Deficits in the numbers and/or function of Tregs may be an underlying …

Viral infections are a natural part of our existence. They can affect us in many ways that are
the result of the interaction between the viral pathogen and our immune system. Most times …