Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies

P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Cell therapy trials for heart regeneration—lessons learned and future directions

P Menasché - Nature Reviews Cardiology, 2018 - nature.com
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy
have been assessed in several clinical trials. These trials can be categorized as those using …

Stem cell therapy for chronic ischaemic heart disease and congestive heart failure

SA Fisher, C Doree, A Mathur… - Cochrane Database …, 2016 - cochranelibrary.com
Background A promising approach to the treatment of chronic ischaemic heart disease and
congestive heart failure is the use of stem cells. The last decade has seen a plethora of …

Synthetic mRNA encoding VEGF-A in patients undergoing coronary artery bypass grafting: design of a phase 2a clinical trial

V Anttila, A Saraste, J Knuuti, P Jaakkola… - … therapy Methods & …, 2020 - cell.com
Therapeutic angiogenesis may improve outcomes in patients with coronary artery disease
undergoing surgical revascularization. Angiogenic factors may promote blood vessel growth …

Meta-analysis of cell therapy trials for patients with heart failure

SA Fisher, C Doree, A Mathur… - Circulation …, 2015 - Am Heart Assoc
Rationale: Cell-based therapies are a promising intervention for the treatment of heart failure
(HF) secondary to ischemic and nonischemic cardiomyopathy. However, the clinical efficacy …

Design of injectable materials to improve stem cell transplantation

LM Marquardt, SC Heilshorn - Current stem cell reports, 2016 - Springer
Stem cell-based therapies are steadily gaining traction for regenerative medicine
approaches to treating disease and injury throughout the body. While a significant body of …

Adult stem cells for regenerative therapy

N Gurusamy, A Alsayari, S Rajasingh… - Progress in molecular …, 2018 - Elsevier
Cell therapy has been identified as an effective method to regenerate damaged tissue. Adult
stem cells, also known as somatic stem cells or resident stem cells, are a rare population of …

Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

E Cambria, FS Pasqualini, P Wolint, J Günter… - NPJ Regenerative …, 2017 - nature.com
Acute myocardial infarction and chronic heart failure rank among the major causes of
morbidity and mortality worldwide. Except for heart transplantation, current therapy options …

Global position paper on cardiovascular regenerative medicine

F Fernández-Avilés, R Sanz-Ruiz… - European heart …, 2017 - academic.oup.com
Based on the increasingly understood regenerative capacity of the human heart and
vascular system, 1 cardiovascular regenerative medicine (CRM) encompasses all potential …

Approaches to therapeutic angiogenesis for ischemic heart disease

T Johnson, L Zhao, G Manuel, H Taylor… - Journal of Molecular …, 2019 - Springer
Ischemic heart disease (IHD) is caused by the narrowing of arteries that work to provide
blood, nutrients, and oxygen to the myocardial tissue. The worldwide epidemic of IHD …