Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …

Salvianolic acid B (Sal B) is one of the main active ingredients of Salvia miltiorrhiza, with
strong antioxidant effects. Recent findings have shown that Sal B has anti-inflammatory, anti …

Depression is the most prevalent and debilitating mental disorder that affects a substantial
number of people globally, hindering all aspects of their lives and leading to a high number …

Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than
the general population. An etiological trigger of depressive symptoms is theorised to be …

Background The natural compound asperosaponin VI has shown potential as an
antidepressant, but how it works is unclear. Here, we explored its effects on mice exposed to …

Acute or chronic liver injury is associated with hyperammonemia which induced
neuroinflammation and oxidative stress in the brain. Neuroinflammation, oxidative stress …

Exposure to early adversity increases vulnerability to psychiatric disorders in later life.
Microglia-mediated inflammation has been linked to psychopathology, so such inflammation …

Salvianolic acid B (SalB), a natural polyphenolic compound extracted from the herb of Salvia
miltiorrhiza, possesses antioxidant and neuroprotective properties and has been shown to …