Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
responses to infection (Third International Consensus definition for Sepsis and septic …

After allogeneic blood or bone marrow transplantation, donor T cells interact with a distorted
antigen-presenting cell (APC) environment in which some, but not all, host APCs are …

Individuals with acute myeloid leukemia (AML) harboring an internal tandem duplication
(ITD) in the gene encoding Fms-related tyrosine kinase 3 (FLT3) who relapse after …

IL-15 is currently undergoing clinical trials to assess its efficacy for treatment of advanced
cancers. The combination of IL-15 with soluble IL-15Rα generates a complex termed IL-15 …

The expansion of the cytokine-producing CD56 bright NK cell subset is a main feature of
lymphocyte reconstitution after allogeneic hematopoietic stem cell transplantation (HSCT) …

The common γ chain (CD132) is a subunit of the interleukin (IL) receptors for IL-2, IL-4, IL-7,
IL-9, IL-15, and IL-21. Because levels of several of these cytokines were shown to be …

Although chronic graft-versus-host disease (cGVHD) is a major long-term complication of
allogeneic hematopoietic stem cell transplantation, little is known of its pathogenesis. We …

Building on a solid foundation of knowledge and skills, this classic text from trusted author
Mary Louise Turgeon clearly explains everything from basic immunologic mechanisms and …

Chronic Graft-versus-Host Disease is a life-threatening inflammatory condition that affects
many patients after allogeneic hematopoietic stem cell transplantation. Although we have …

Interleukin (IL)-15 belongs to the common gamma-dependent cytokine family, along with IL-
2, IL-4, IL-7, IL-9, and IL-21. IL-15 is crucial for the homeostasis of Natural Killer (NK) and …