AIM The “2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial
Fibrillation” provides recommendations to guide clinicians in the treatment of patients with …

CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …

Engineering smart nano-therapeutics for re-epithelialisation of chronic wounds facilitates the
wound healing process. However, due to excessive oxidative stress damage and persistent …

The modification of nuclear, mitochondrial, and cytosolic proteins by O-linked βN-
acetylglucosamine (O-GlcNAc) has emerged as a dynamic and essential post-translational …

Rationale: Diabetic hyperglycemia is associated with cardiac dysfunction and increased
arrhythmia risk, and CaMKII (calcium/calmodulin-dependent protein kinase II) function has …

Background: Heart failure is a leading cause of death worldwide and is associated with the
rising prevalence of obesity, hypertension, and diabetes. O-GlcNAcylation (the attachment of …

The development of the foetal heart is driven by increased glucose uptake and activation of
mammalian target of rapamycin (mTOR) and hypoxia‐inducible factor‐1α (HIF‐1α), which …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) hyperactivity causes cardiac
arrhythmias, a major source of morbidity and mortality worldwide. Despite proven benefits of …

The dynamic cycling of O-linked GlcNAc (O-GlcNAc) on and off Ser/Thr residues of
intracellular proteins, termed O-GlcNAcylation, is mediated by the conserved enzymes O …

Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and its prevalence
increases with age. The irregular and rapid contraction of the atria can lead to ineffective …