Butyrate is a short-chain fatty acid produced by colonic gut bacteria as a result of
fermentation of dietary fibers. In the colon, butyrate is a major energy substrate and …

Receptor for advanced glycation end-products (RAGE) is a multiligand binding and single-
pass transmembrane protein taken in diverse chronic inflammatory conditions. RAGE …

Manipulation of gut microbiota by bacterial metabolites has shown protective effects against
colitis; while the efficacy is strictly limited by the poor oral delivery efficiency and single drug …

Introduction The tumor microenvironment (TME) in colorectal cancer (CRC) includes the gut
microbiome, immune cells, angiogenic factors, and fibroblasts and plays a major role in …

The gut–liver axis plays important roles in both the maintenance of a healthy liver and the
pathogenesis of liver diseases, where the gut microbiota acts as a major determinant of this …

Herbal medicines (HMs) are a major subset of complementary and alternative medicine.
They have been employed for the efficient clinical management of type 2 diabetes mellitus …

HMGB1 is a ubiquitously expressed protein localized in nucleus, cytoplasm, as well as
secreted into extracellular space. Nuclear HMGB1 binds to DNAs and RNAs, regulating …

Background and aims Anastomotic leak (AL) is a major complication in colorectal surgery.
Recent evidence suggests that the gut microbiota may affect healing and may cause or …

Advanced glycation end products (AGEs) are produced in response to a high-glucose
environment and oxidative stress and exacerbate various diseases. N ε-(Carboxymethyl) …

Background: Sulforaphane (SFN), a phytochemical compound, which belongs to
isothiocyanates family found in abundance in broccoli sprouts, potently induces a variety of …