Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease

JH Laragh, L Baer, HR Brunner, FR Buhler… - The American journal of …, 1972 - Elsevier
The renin angiotensin aldosterone concatenation, via two effector components, angiotensin
II and aldosterone, simultaneously regulates (1) body sodium and water content,(2) arterial …

Conversion of angiotensin I to angiotensin II

EG Erdös - The American journal of medicine, 1976 - Elsevier
The angiotensin I converting enzyme has two important functions: it inactivates bradykinin
and converts angiotensin I to angiotensin II. Inhibition of the enzyme blocks the renin …

Dopamine-sensitive adenyl cyclase: possible role in synaptic transmission

JW Kebabian, P Greengard - Science, 1971 - science.org
An adenyl cyclase activated by low concentrations of dopamine has been found in the
mammalian superior cervical sympathetic ganglion. The existence of this enzyme may …

Angiotensin-converting enzyme: vascular endothelial localization

PRB Caldwell, BC Seegal, KC Hsu, M Das, RL Soffer - Science, 1976 - science.org
Fluorescein-labeled antibody to rabbit pulmonary angiotensin-converting enzyme localized
in the vascular endothelium of rabbit lung, liver, adrenal cortex, pancreas, kidney, and …

Angiotensin I converting enzyme.

EG Erdös - Circulation Research, 1975 - Am Heart Assoc
• Interest in particular biologically active substances waxes and wanes. Investigators rush
into a newly opened field, solve a few problems, and frequently raise more; then they rush …

Hypertension of renal origin: evidence for two different mechanisms

HR Brunner, JD Kirshman, JE Sealey, JH Laragh - Science, 1971 - science.org
Antibody to angiotensin II, or a specific peptide competitive inhibitor of angiotensin II, was
used to investigate the role of the renin-angiotensin system in two types of renal …

Inhibition of homogeneous angiotensin-converting enzyme of rabbit lung by synthetic venom peptides of Bothrops jararaca

HS Cheung, DW Cushman - Biochimica et Biophysica Acta (BBA) …, 1973 - Elsevier
Seven synthetic peptides, identical to those found in the venom of Bothrops jararaca,
inhibited the peptidolytic activity of homogeneous (275-fold purified) angiotensin-converting …

Non-enzymatic proteins from snake venoms: a gold mine of pharmacological tools and drug leads

RJR McCleary, RM Kini - Toxicon, 2013 - Elsevier
Non-enzymatic proteins from snake venoms play important roles in the immobilization of
prey, and include some large and well-recognized families of toxins. The study of such …

An angiotensin converting-enzyme inhibitor to identify and treat vasoconstrictor and volume factors in hypertensive patients

H Gavras, HR Brunner, JH Laragh… - … England Journal of …, 1974 - Mass Medical Soc
The antihypertensive action of nonapeptide competitive inhibitor of angiotensin-1-converting
enzyme was evaluated in 13 hypertensive patients. In 12 a single injection (1 to 4 mg per …

The biochemistry of the renin-angiotensin system and its role in hypertension

LT Skeggs, FE Dorer, JR Kahn, KE Lentz… - The American journal of …, 1976 - Elsevier
The renin-angiotensin system has an important role in maintaining elevated blood pressure
levels in certain forms of experimental and human hypertension. Renin, an enzyme …