The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long
been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who …

Lymphoid tissue is a key reservoir established by HIV-1 during acute infection. It is a site
associated with viral production, storage of viral particles in immune complexes, and viral …

APOBEC-catalyzed cytosine-to-uracil deamination of single-stranded DNA (ssDNA) has
beneficial functions in immunity and detrimental effects in cancer. APOBEC enzymes have …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has
facilitated the study of viral genome evolution over a brief period of time. This has …

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC)
mutational signature has only recently been detected in a multitude of cancers through next …

Human DNA cytosine-to-uracil deaminases catalyze mutations in both pathogen and
cellular genomes. APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H restrict human …

Apolipoprotein B editing complex 3 family members are cytidine deaminases that play
important roles in intrinsic responses to infection by retroviruses and have been implicated …

The apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like (APOBEC)
family of single-stranded DNA (ssDNA) cytosine deaminases provides innate immunity …