Induction of broadly cross-reactive neutralizing antibodies (NAb) is an important goal for a
prophylactic human immunodeficiency virus type 1 (HIV-1) vaccine. Some HIV-infected …

The transforming growth factor-β (TGF-β) signalling pathway plays a critical role in
carcinogenesis. It has a biphasic action by initially suppressing tumorigenesis but promoting …

The unfolded protein response (UPR) and autophagy are two cellular environmental
responses that affect a cell's life or death. The UPR begins on the sensing of an excess of …

ABSTRACT The Epstein-Barr virus (EBV) predominantly establishes latent infection in B
cells, and the reactivation of the virus from latency is dependent on the expression of the …

Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive
lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence …

Reactivation of lytic replication from viral latency is a defining property of all herpesviruses.
Despite this, the authentic physiological cues for the latent-lytic switch are unclear. Such …

Infection of inbred mice with murine gammaherpesvirus 68 (MHV68) has proven to be a
powerful tool to study gammaherpesvirus pathogenesis. However, one of the limitations of …

ABSTRACT Activation of the Epstein-Barr virus (EBV) lytic cycle is mediated through the
combined actions of ZEBRA and Rta, the products of the viral BZLF1 and BRLF1 genes …

During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity
of the protein folding and quality control machinery, leading to an accumulation of unfolded …

Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus and the
cause of Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's …