Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Despite evidence that SARS-CoV-2 infection is systemic in nature, there is little known about
the effects that SARS-CoV-2 infection or exposure has on many host cell types, including …

The differentiation shift from osteogenesis to adipogenesis of bone marrow mesenchymal
stem cells (BMSCs) characterizes many pathological bone loss conditions. Stromal cell …

The first hematopoietic transplant in which umbilical cord blood (UCB) was used as the
source of hematopoietic cells was performed in October 1988. Since then, significant …

Background Chemotherapy can induce premature ovarian insufficiency (POI). POI causes
multiple sequelae and is currently incurable. As shown in our previous studies, systemically …

Histone deacetylases (HDACs) are a group of enzymes that catalyze the removal of acetyl
groups from histone and nonhistone proteins. HDACs have been shown to have diverse …

Background The imbalance of osteogenic/adipogenic differentiation of bone marrow
mesenchymal stem cells (BMSCs) is closely related to steroid-induced avascular necrosis of …

Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state
of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion …

Glioma is among the deadliest types of brain cancer, for which there currently is no effective
treatment. Chemotherapy is mainstay in the treatment of glioma. However, drug tolerance …

In contrast to the short-term (ST) CD34+ stem cells, studies have suggested that long-term
(LT) hematopoietic stem cells (HSCs) found in the CD34− stem cell pool have trouble …