Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on
proteins as detection units (eg antibodies) to sense for analytes. Glycans play a fundamental …

Glycans govern cellular signaling through glycan–protein and glycan–glycan crosstalk.
Disruption in the crosstalk initiates 'rogue'signaling and pathology. Nanomaterials supply …

The COVID-19 pandemic has highlighted the need for innovative biosensing, diagnostic,
and surveillance platforms. Here we report that glycosylated, polymer-stabilized, gold …

The multivalent presentation of glycans leads to enhanced binding avidity to lectins due to
the cluster glycoside effect. Most materials used as scaffolds for multivalent glycan arrays …

Upon exposure to biological fluids, the fouling of nanomaterial surfaces results in non-
specific capture of proteins, which is particularly important when in contact with blood for in …

Since the outbreak of the pandemic respiratory virus SARS-CoV-2 (COVID-19), academic
communities and governments/private companies have used several detection techniques …

Glycan-mediated interactions play a crucial role in biology and medicine, influencing
signalling, immune responses, and disease pathogenesis. However, the use of glycans in …

Lateral flow immuno‐assays, such as the home pregnancy test, are rapid point‐of‐care
diagnostics that use antibody‐coated nanoparticles to bind antigens/analytes (eg, viruses …

In structural terms, the sialic acids are a large family of nine carbon sugars based around an
alpha-keto acid core. They are widely spread in nature, where they are often found to be …

Mannose-binding lectin (MBL) activates the complement system lectin pathway and
subsequent inflammatory mechanisms. The incidence and outcome of many human …