Biological role of unsaturated fatty acid desaturases in health and disease
A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …
of cells that influence normal development and function of many organisms, both eukaryotes …
Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies
Personalized nutrition (PN) has gained much attention as a tool for empowerment of
consumers to promote changes in dietary behavior, optimizing health status and preventing …
consumers to promote changes in dietary behavior, optimizing health status and preventing …
Age‐related changes to macrophages are detrimental to fracture healing in mice
D Clark, S Brazina, F Yang, D Hu, CL Hsieh… - Aging cell, 2020 - Wiley Online Library
The elderly population suffers from higher rates of complications during fracture healing that
result in increased morbidity and mortality. Inflammatory dysregulation is associated with …
result in increased morbidity and mortality. Inflammatory dysregulation is associated with …
A comprehensive multi-task deep learning approach for predicting metabolic syndrome with genetic, nutritional, and clinical data
M Lee, T Park, JY Shin, M Park - Scientific Reports, 2024 - nature.com
Metabolic syndrome (MetS) is a complex disorder characterized by a cluster of metabolic
abnormalities, including abdominal obesity, hypertension, elevated triglycerides, reduced …
abnormalities, including abdominal obesity, hypertension, elevated triglycerides, reduced …
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
M D'Antonio, JP Nguyen, TD Arthur, H Matsui… - Cell reports, 2021 - cell.com
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between
individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive …
individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive …
Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation
Human diets in developed countries such as the US have changed dramatically over the
past 75 years, leading to increased obesity, inflammation, and cardiometabolic dysfunction …
past 75 years, leading to increased obesity, inflammation, and cardiometabolic dysfunction …
Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis
AM Kulminski, E Loiko, Y Loika, I Culminskaya - Geroscience, 2022 - Springer
Epidemiological studies report beneficial associations of higher educational attainment
(EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also …
(EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also …
Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations
DC Rinker, CN Simonti, E McArthur, D Shaw… - Nature ecology & …, 2020 - nature.com
Neanderthal ancestry remains across modern Eurasian genomes and introgressed
sequences influence diverse phenotypes. Here, we demonstrate that introgressed …
sequences influence diverse phenotypes. Here, we demonstrate that introgressed …
Exome-wide association study identified clusters of pleiotropic genetic associations with Alzheimer's disease and thirteen cardiovascular traits
Y Loika, E Loiko, I Culminskaya, AM Kulminski - Genes, 2023 - mdpi.com
Alzheimer's disease (AD) and cardiovascular traits might share underlying causes. We
sought to identify clusters of cardiovascular traits that share genetic factors with AD. We …
sought to identify clusters of cardiovascular traits that share genetic factors with AD. We …
Genomic basis of insularity and ecological divergence in barn owls (Tyto alba) of the Canary Islands
Islands, and the particular organisms that populate them, have long fascinated biologists.
Due to their isolation, islands offer unique opportunities to study the effect of neutral and …
Due to their isolation, islands offer unique opportunities to study the effect of neutral and …