Biological role of unsaturated fatty acid desaturases in health and disease

A Czumaj, T Śledziński - Nutrients, 2020 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components
of cells that influence normal development and function of many organisms, both eukaryotes …

Omics biomarkers and an approach for their practical implementation to delineate health status for personalized nutrition strategies

J Keijer, X Escoté, S Galmés… - Critical reviews in …, 2024 - Taylor & Francis
Personalized nutrition (PN) has gained much attention as a tool for empowerment of
consumers to promote changes in dietary behavior, optimizing health status and preventing …

Age‐related changes to macrophages are detrimental to fracture healing in mice

D Clark, S Brazina, F Yang, D Hu, CL Hsieh… - Aging cell, 2020 - Wiley Online Library
The elderly population suffers from higher rates of complications during fracture healing that
result in increased morbidity and mortality. Inflammatory dysregulation is associated with …

A comprehensive multi-task deep learning approach for predicting metabolic syndrome with genetic, nutritional, and clinical data

M Lee, T Park, JY Shin, M Park - Scientific Reports, 2024 - nature.com
Metabolic syndrome (MetS) is a complex disorder characterized by a cluster of metabolic
abnormalities, including abdominal obesity, hypertension, elevated triglycerides, reduced …

SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues

M D'Antonio, JP Nguyen, TD Arthur, H Matsui… - Cell reports, 2021 - cell.com
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between
individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive …

Interpreting Clinical Trials With Omega-3 Supplements in the Context of Ancestry and FADS Genetic Variation

FH Chilton, A Manichaikul, C Yang, TD O'Connor… - Frontiers in …, 2022 - frontiersin.org
Human diets in developed countries such as the US have changed dramatically over the
past 75 years, leading to increased obesity, inflammation, and cardiometabolic dysfunction …

Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis

AM Kulminski, E Loiko, Y Loika, I Culminskaya - Geroscience, 2022 - Springer
Epidemiological studies report beneficial associations of higher educational attainment
(EDU) with Alzheimer's disease (AD). Prior genome-wide association studies (GWAS) also …

Neanderthal introgression reintroduced functional ancestral alleles lost in Eurasian populations

DC Rinker, CN Simonti, E McArthur, D Shaw… - Nature ecology & …, 2020 - nature.com
Neanderthal ancestry remains across modern Eurasian genomes and introgressed
sequences influence diverse phenotypes. Here, we demonstrate that introgressed …

Exome-wide association study identified clusters of pleiotropic genetic associations with Alzheimer's disease and thirteen cardiovascular traits

Y Loika, E Loiko, I Culminskaya, AM Kulminski - Genes, 2023 - mdpi.com
Alzheimer's disease (AD) and cardiovascular traits might share underlying causes. We
sought to identify clusters of cardiovascular traits that share genetic factors with AD. We …

Genomic basis of insularity and ecological divergence in barn owls (Tyto alba) of the Canary Islands

T Cumer, AP Machado, F Siverio, SI Cherkaoui… - Heredity, 2022 - nature.com
Islands, and the particular organisms that populate them, have long fascinated biologists.
Due to their isolation, islands offer unique opportunities to study the effect of neutral and …