Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …

Inflammasomes are intracellular complexes involved in the innate immunity that convert
proIL‐1β and proIL‐18 to mature forms and initiate pyroptosis via cleaving procaspase‐1 …

Secretion of the cytokine interleukin-1β (IL-1β) by macrophages, a major driver of
pathogenesis in atherosclerosis, requires two steps: Priming signals promote transcription of …

The recognition of invading pathogens and endogenous molecules from damaged tissues
by toll-like receptors (TLRs) triggers protective self-defense mechanisms. However …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Atherosclerotic vascular disease (ASVD) is a chronic process, with a progressive course
over many years, but it can cause acute clinical events, including acute coronary syndromes …

Aims Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease;
however, the molecular mechanism remains largely unknown. Endogenous DNA fragments …

Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are
characterized by a chronic sterile inflammation in the large blood vessels, where lipid …

Atherosclerosis has long been known as an inflammatory disease. However, whether
targeting inflammation improves outcomes was unproven until the recent results of CANTOS …

Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …