Cancer metastasis remains the most lethal characteristic of tumors mediating the majority of
cancer-related deaths. Identifying key molecules responsible for metastasis, understanding …

Drug transporters are essential players in the transmembrane transport of a wide variety of
clinical drugs. The broad substrate spectra and versatile distribution pattern of these …

The relationship between interactions, flexibility and disorder in proteins has been explored
from many angles over the years: folding upon binding, flexibility of the core relative to the …

Human D-3-phosphoglycerate dehydrogenase (PHGDH), a key enzyme in de novo serine
biosynthesis, is amplified in various cancers and serves as a potential target for anticancer …

In Type 2 diabetes, increased insulin sensitivity is induced by thiazolidinedione activation of
the peroxisome proliferator-activated receptor gamma (PPARγ). Recent data indicate a …

In this work, we investigated how activity and oligomeric state are related in a purified GH1 β‐
glucosidase from Spodoptera frugiperda (Sfβgly). Gel filtration chromatography coupled to a …

Allostery and molecular machines | Philosophical Transactions of the Royal Society B:
Biological Sciences logo logo Skip main navigationJournal menuClose Drawer MenuOpen …

Interrupted dimeric coiled coil segments are found in a broad range of proteins and
generally confer selective functional properties such as binding to specific ligands. However …

Chemokine ligands play a pivotal role in immune response by mediating cell migration and
coordinating cellular processes through interactions with chemokine receptors …

Human FoxP proteins share a highly conserved DNA‐binding domain that dimerizes via
three‐dimensional domain swapping, although showing varying oligomerization …