[HTML][HTML] Small nucleolar RNAs: insight into their function in cancer

J Liang, J Wen, Z Huang, X Chen, B Zhang… - Frontiers in …, 2019 - frontiersin.org
Small nucleolar RNAs (SnoRNAs) are a class of non-coding RNAs divided into two classes:
C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA …

[HTML][HTML] tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus …

X Yu, Y Xie, S Zhang, X Song, B Xiao, Z Yan - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract tRNA-derived fragments (tRFs) are a new category of regulatory noncoding RNAs
with distinct biological functions in cancers and stress-induced diseases. Herein, we first …

[HTML][HTML] Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

MJ Shurtleff, MM Temoche-Diaz, KV Karfilis, S Ri… - elife, 2016 - elifesciences.org
Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

MJ Shurtleff, J Yao, Y Qin… - Proceedings of the …, 2017 - National Acad Sciences
RNA is secreted from cells enclosed within extracellular vesicles (EVs). Defining the RNA
composition of EVs is challenging due to their coisolation with contaminants, lack of …

tRNA-derived fragments and tRNA halves: the new players in cancers

L Zhu, J Ge, T Li, Y Shen, J Guo - Cancer Letters, 2019 - Elsevier
Abstract tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs) are small non-coding
RNAs derived from precursor tRNAs or mature tRNAs. Depending on the sources, tRFs can …

[HTML][HTML] tRNA-derived fragments (tRFs): emerging new roles for an ancient RNA in the regulation of gene expression

SP Keam, G Hutvagner - Life, 2015 - mdpi.com
This review will summarise the recent discoveries and current state of research on short
noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will …

[HTML][HTML] Cold shock proteins: from cellular mechanisms to pathophysiology and disease

JA Lindquist, PR Mertens - Cell Communication and Signaling, 2018 - Springer
Cold shock proteins are multifunctional RNA/DNA binding proteins, characterized by the
presence of one or more cold shock domains. In humans, the best characterized members of …

Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease

R Khurana, G Ranches, S Schafferer, M Lukasser… - Rna, 2017 - rnajournal.cshlp.org
In chronic kidney disease (CKD), the decline in the glomerular filtration rate is associated
with increased morbidity and mortality and thus poses a major challenge for healthcare …

[HTML][HTML] Y-box binding proteins in mRNP assembly, translation, and stability control

D Mordovkina, DN Lyabin, EA Smolin, EM Sogorina… - Biomolecules, 2020 - mdpi.com
Y-box binding proteins (YB proteins) are DNA/RNA-binding proteins belonging to a large
family of proteins with the cold shock domain. Functionally, these proteins are known to be …

[HTML][HTML] snoRNPs: functions in ribosome biogenesis

S Ojha, S Malla, SM Lyons - Biomolecules, 2020 - mdpi.com
Ribosomes are perhaps the most critical macromolecular machine as they are tasked with
carrying out protein synthesis in cells. They are incredibly complex structures composed of …