DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice
M de Boer, M te Lintel Hekkert, J Chang… - Aging …, 2023 - Wiley Online Library
Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …
Rejuvenation of the Aging Heart: Molecular Determinants and Applications
FJ Alibhai, RK Li - Canadian Journal of Cardiology, 2024 - Elsevier
In Canada and worldwide, the elderly population (ie, individuals> 65 years of age) is
increasing disproportionately relative to the total population. This is expected to have a …
increasing disproportionately relative to the total population. This is expected to have a …
[HTML][HTML] Viral Myocarditis as a Factor Leading to the Development of Heart Failure Symptoms, Including the Role of Parvovirus B19 Infection—Systematic Review
S Krych, A Jęczmyk, M Jurkiewicz, M Żurek… - International Journal of …, 2024 - mdpi.com
Myocarditis (MC) is defined as an immunological inflammatory reaction with various
etiologies, clinical presentations and prognoses within the myocardium. Currently …
etiologies, clinical presentations and prognoses within the myocardium. Currently …
DNA double-stranded breaks, a hallmark of aging, defined at the nucleotide resolution, are increased and associated with transcription in the cardiac myocytes in …
B Cathcart, SM Cheedipudi, L Rouhi… - Cardiovascular …, 2024 - academic.oup.com
Aims An intrinsic feature of gene transcription is the formation of DNA superhelices near the
transcription bubble, which are resolved upon induction of transient double-stranded breaks …
transcription bubble, which are resolved upon induction of transient double-stranded breaks …
Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence
B Li, W Xiong, W Zuo, Y Shi, T Wang… - Nucleic Acids …, 2024 - academic.oup.com
Telomeres, TTAGGGn DNA repeat sequences located at the ends of eukaryotic
chromosomes, play a pivotal role in aging and are targets of DNA damage response …
chromosomes, play a pivotal role in aging and are targets of DNA damage response …
PGAM5 interacts with and maintains BNIP3 to license cancer-associated muscle wasting
Q Zhang, C Chen, Y Ma, X Yan, N Lai, H Wang, B Gao… - Autophagy, 2024 - Taylor & Francis
Regressing the accelerated degradation of skeletal muscle protein is a significant goal for
cancer cachexia management. Here, we show that genetic deletion of Pgam5 ameliorates …
cancer cachexia management. Here, we show that genetic deletion of Pgam5 ameliorates …
The role of cardiomyocyte senescence in cardiovascular diseases: a molecular biology update
S He, L Yan, C Yuan, W Li, T Wu, S Chen, N Li… - European Journal of …, 2024 - Elsevier
Cardiovascular diseases (CVD) are the leading cause of death worldwide, and advanced
age is a main contributor to the prevalence of CVD. Cellular senescence is an irreversible …
age is a main contributor to the prevalence of CVD. Cellular senescence is an irreversible …
Replication-independent ICL repair: from chemotherapy to cell homeostasis
A Ahmed, N Kato, J Gautier - Journal of Molecular Biology, 2024 - Elsevier
Interstrand crosslinks (ICLs) are a type of covalent lesion that can prevent transcription and
replication by inhibiting DNA strand separation and instead trigger cell death. ICL inducing …
replication by inhibiting DNA strand separation and instead trigger cell death. ICL inducing …
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
BS van Thiel, M de Boer, Y Ridwan… - Molecular Imaging and …, 2024 - Springer
Purpose In this study, we explored the role of apoptosis as a potential biomarker for cardiac
failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging …
failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging …
Multi-level transcriptomic analysis of LMNA-related dilated cardiomyopathy identifies disease-driving processes
LMNA-related dilated cardiomyopathy (LMNA-DCM) is one of the most severe forms of
DCM. The incomplete understanding of the molecular disease mechanisms results in …
DCM. The incomplete understanding of the molecular disease mechanisms results in …