Heart failure has reached epidemic proportions in a progressively ageing population. The
molecular mechanisms underlying heart failure remain elusive, but evidence indicates that …

In Canada and worldwide, the elderly population (ie, individuals> 65 years of age) is
increasing disproportionately relative to the total population. This is expected to have a …

Myocarditis (MC) is defined as an immunological inflammatory reaction with various
etiologies, clinical presentations and prognoses within the myocardium. Currently …

Aims An intrinsic feature of gene transcription is the formation of DNA superhelices near the
transcription bubble, which are resolved upon induction of transient double-stranded breaks …

Telomeres, TTAGGGn DNA repeat sequences located at the ends of eukaryotic
chromosomes, play a pivotal role in aging and are targets of DNA damage response …

Regressing the accelerated degradation of skeletal muscle protein is a significant goal for
cancer cachexia management. Here, we show that genetic deletion of Pgam5 ameliorates …

Cardiovascular diseases (CVD) are the leading cause of death worldwide, and advanced
age is a main contributor to the prevalence of CVD. Cellular senescence is an irreversible …

Interstrand crosslinks (ICLs) are a type of covalent lesion that can prevent transcription and
replication by inhibiting DNA strand separation and instead trigger cell death. ICL inducing …

Purpose In this study, we explored the role of apoptosis as a potential biomarker for cardiac
failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging …

LMNA-related dilated cardiomyopathy (LMNA-DCM) is one of the most severe forms of
DCM. The incomplete understanding of the molecular disease mechanisms results in …