[HTML][HTML] Carbohydrate-based drugs launched during 2000− 2021

X Cao, X Du, H Jiao, Q An, R Chen, P Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …

Recent updates on phytoconstituent alpha-glucosidase inhibitors: An approach towards the treatment of type two diabetes

H Kashtoh, KH Baek - Plants, 2022 - mdpi.com
Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels,
which can lead to serious consequences such as retinopathy, diabetic neuropathy and …

Natural products for the treatment of type 2 diabetes mellitus

JL Ríos, F Francini, GR Schinella - Planta medica, 2015 - thieme-connect.com
Type 2 diabetes mellitus is a metabolic disease characterized by persistent hyperglycemia.
High blood sugar can produce long-term complications such as cardiovascular and renal …

[PDF][PDF] Medicinal natural products: A biosynthetic approach

PM Dewick - 2002 - just.edu.jo
Medicinal Natural Products, Second Edition is a comprehensive guide providing information
on all classes of natural products in medicine. It builds upon fundamental chemical …

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: an evidence-based review

SR Joshi, E Standl, N Tong, P Shah… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Postprandial hyperglycemia (PPHG) contributes to micro-and macro-vascular
complications more than fasting hyperglycemia in patients with type 2 diabetes mellitus. Due …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

H Sheng, H Sun - Natural product reports, 2011 - pubs.rsc.org
Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …

[HTML][HTML] Novel thymol bearing oxypropanolamine derivatives as potent some metabolic enzyme inhibitors–Their antidiabetic, anticholinergic and antibacterial …

M Zengin, H Genc, P Taslimi, A Kestane, E Guclu… - Bioorganic …, 2018 - Elsevier
A series of classical and newly synthesized thymol bearing oxypropanolamine compounds
were synthesized and characterized. Their in vitro antibacterial activity on A. baumannii, P …

[HTML][HTML] Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2, 5-dione and thiazolidine-2, 4-dione …

F Hussain, Z Khan, MS Jan, S Ahmad, A Ahmad… - Bioorganic …, 2019 - Elsevier
Abstract α-Glucosidase is considered as a therapeutic target for the treatment of type 2
diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2, 5-dione …

Strategies for the development of glycomimetic drug candidates

R Hevey - Pharmaceuticals, 2019 - mdpi.com
Carbohydrates are a structurally-diverse group of natural products which play an important
role in numerous biological processes, including immune regulation, infection, and cancer …