Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

M Kebschull, RT Demmer… - Journal of dental …, 2010 - journals.sagepub.com
Evidence from epidemiologic studies suggests that periodontal infections are independently
associated with subclinical and clinical atherosclerotic vascular disease. Although the …

Relationship between periodontal infections and systemic disease

GJ Seymour, PJ Ford, MP Cullinan… - Clinical Microbiology …, 2007 - Wiley Online Library
Oral conditions such as gingivitis and chronic periodontitis are found worldwide and are
among the most prevalent microbial diseases of mankind. The cause of these common …

Immune mechanisms in atherosclerosis

GK Hansson - Arteriosclerosis, thrombosis, and vascular biology, 2001 - Am Heart Assoc
Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can
orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis …

Heat shock proteins in infection

A Bolhassani, E Agi - Clinica Chimica Acta, 2019 - Elsevier
Heat shock proteins (HSPs) are constitutively expressed under physiological conditions in
most organisms but their expression can significantly enhance in response to four types of …

Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease

B Henderson, A Martin - Infection and immunity, 2011 - Am Soc Microbiol
Men may not be able to multitask, but it is emerging that proteins can. This capacity of
proteins to exhibit more than one function is termed protein moonlighting, and, surprisingly …

Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study

S Kiechl, G Egger, M Mayr, CJ Wiedermann, E Bonora… - Circulation, 2001 - Am Heart Assoc
Background—Chronic infections have been implicated in the pathogenesis of
atherosclerosis, yet from an epidemiological perspective, this concept remains controversial …

Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E–null mice

E Lalla, IB Lamster, MA Hofmann… - … , and vascular biology, 2003 - Am Heart Assoc
Objective—Because recent epidemiologic evidence suggests that periodontal infections
may increase the risk of atherosclerosis and related events in humans, we assessed the …

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice

R Elhage, J Jawien, M Rudling… - Cardiovascular …, 2003 - academic.oup.com
Objective: Atherosclerosis is an inflammatory disease in which T helper 1 (Th1) immunity
has been proposed to play an important role. Naı̈ve CD4+ T cells differentiate into …

Role of heat shock proteins in atherosclerosis

Q Xu - Arteriosclerosis, thrombosis, and vascular biology, 2002 - Am Heart Assoc
Heat shock proteins (HSPs) are present in most cells, serving as molecular chaperones, and
they play a role in cell protection from damage in response to stress stimuli. However …

Atherothrombosis, inflammation, and diabetes

GGL Biondi-Zoccai, A Abbate, G Liuzzo… - Journal of the American …, 2003 - jacc.org
Diabetes represents a major cause of cardiovascular morbidity and mortality in developed
countries, and atherothrombosis accounts for most deaths among diabetics. Recent …