[HTML][HTML] Integrating cellular electron microscopy with multimodal data to explore biology across space and time
Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …
[HTML][HTML] The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography
S Li, JJ Fernandez, MD Ruehle, RA Howard-Till… - …, 2024 - pmc.ncbi.nlm.nih.gov
The cilium is a microtubule-based organelle critical for many cellular functions. Its assembly
initiates at a basal body and continues as an axoneme that projects out of the cell to form a …
initiates at a basal body and continues as an axoneme that projects out of the cell to form a …
[HTML][HTML] Structures of Native Doublet Microtubules from Trichomonas vaginalis Reveal Parasite-Specific Proteins as Potential Drug Targets
A Stevens, S Kashyap, EH Crofut, SE Wang… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Doublet microtubules (DMTs) are flagellar components required for the protist Trichomonas
vaginalis (Tv) to swim through the human genitourinary tract to cause trichomoniasis, the …
vaginalis (Tv) to swim through the human genitourinary tract to cause trichomoniasis, the …
Structure of AcMNPV nucleocapsid reveals DNA portal organization and packaging apparatus of circular dsDNA baculovirus.
Baculoviruses are large DNA viruses found in nature propagating amongst insects and
lepidoptera in particular. Their viral cycle has been studied and characterized over decades …
lepidoptera in particular. Their viral cycle has been studied and characterized over decades …
In-cell structural insight into the asymmetric assembly of central apparatus in mammalian sperm axoneme
In motile cilia or flagella, the axoneme typically exhibits a" 9+ 2" configuration, with the
central apparatus (CA) consisting of extensively modified microtubules C1 and C2 to …
central apparatus (CA) consisting of extensively modified microtubules C1 and C2 to …
DiffFit: Differentiable Fitting of Molecule Structures to a Cryo-EM Map
We introduce DiffFit, a differentiable algorithm for fitting protein atomistic structures into
experimental Cryo-Electron Microscopy (cryo-EM) volume maps. This process is crucial in …
experimental Cryo-Electron Microscopy (cryo-EM) volume maps. This process is crucial in …
Structures of Native Doublet Microtubules from Trichomonas vaginalis Reveal Parasite-Specific Proteins as Potential Drug Targets
Doublet microtubules (DMTs) are flagellar components required for the protist Trichomonas
vaginalis (Tv) to swim through the human genitourinary tract to cause trichomoniasis, the …
vaginalis (Tv) to swim through the human genitourinary tract to cause trichomoniasis, the …