Neuroinflammation: friend and foe for ischemic stroke

RL Jayaraj, S Azimullah, R Beiram, FY Jalal… - Journal of …, 2019 - Springer
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in
perspective with the emergence of new ideas on neurodegeneration. The concept that …

Pathogenic mechanisms following ischemic stroke

SE Khoshnam, W Winlow, M Farzaneh, Y Farbood… - Neurological …, 2017 - Springer
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …

Overview of general and discriminating markers of differential microglia phenotypes

AM Jurga, M Paleczna, KZ Kuter - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Inflammatory processes and microglia activation accompany most of the pathophysiological
diseases in the central nervous system. It is proven that glial pathology precedes and even …

The indispensable roles of microglia and astrocytes during brain development

K Reemst, SC Noctor, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats

J Pearson-Leary, C Zhao, K Bittinger, D Eacret… - Molecular …, 2020 - nature.com
Chronic exposure to stress is associated with increased incidence of depression,
generalized anxiety, and PTSD. However, stress induces vulnerability to such disorders only …

The complex interactions between obesity, metabolism and the brain

RM Uranga, JN Keller - Frontiers in neuroscience, 2019 - frontiersin.org
Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on
the various organ systems of the body is only beginning to be fully appreciated. Because of …

Surveillance, phagocytosis, and inflammation: How never‐resting microglia influence adult hippocampal neurogenesis

A Sierra, S Beccari, I Diaz-Aparicio, JM Encinas… - Neural …, 2014 - Wiley Online Library
Microglia cells are the major orchestrator of the brain inflammatory response. As such, they
are traditionally studied in various contexts of trauma, injury, and disease, where they are …

[HTML][HTML] Dodging blood brain barrier with “nano” warriors: Novel strategy against ischemic stroke

S Parvez, M Kaushik, M Ali, MM Alam, J Ali… - Theranostics, 2022 - ncbi.nlm.nih.gov
Ischemic stroke (IS) is one of the leading causes of death and disability resulting in
inevitable burden globally. Ischemic injury initiates cascade of pathological events …

TSPO modulates IL-4-induced microglia/macrophage M2 polarization via PPAR-γ pathway

D Zhou, L Ji, Y Chen - Journal of Molecular Neuroscience, 2020 - Springer
Microglia activation has been reported to be associated with pathogenesis of
neuroinflammation, central nervous system damage, and degeneration diseases. With …