Next‐generation neural interfaces for bidirectional communication with the central nervous
system aim to achieve the intimate integration with the neural tissue with minimal …

Patients suffering from neuronal degenerative diseases are increasingly being equipped
with neural implants to treat symptoms or restore functions and increase their quality of life …

Interictal epileptiform discharges (IEDs) are a widely used biomarker in patients with
epilepsy but lack specificity. It has been proposed that there are truly epileptogenic and less …

With their 'all-or-none'action potential responses, single neurons (or units) are accepted as
the basic computational unit of the brain. There is extensive animal literature to support the …

Electrical stimulation mapping (ESM) using stereoelectroencephalography (SEEG) is an
essential component in the workup of surgical epilepsy. Since the initial application of ESM …

Objective. Drug resistant focal epilepsy can be treated by resecting the epileptic focus
requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes …

Background: Invasive electrode monitoring provides more precise localization of
epileptogenic foci in patients with medically refractory epilepsy. The use of hybrid depth …

Objective. The authors report methods developed for the implantation of micro-wire bundles
into mesial temporal lobe structures and subsequent single neuron recording in epileptic …

Background Recordings with tetrodes have proven to be more effective in isolating single
neuron spiking activity than with single microwires. However, tetrodes have never been …

Background One-third of all patients with epilepsy have persistent seizures despite medical
treatment. If the origin of the seizures can be localized to a particular site in the brain …