Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …

Diabetes is a global epidemic problem growing exponentially in Asian countries posing a
serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a …

Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …

Abstract Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin. A number of genetic …

To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …

Context: Six maturity onset diabetes of the young (MODY) genes have been discovered to
date but account for a small proportion of MODY among Asians, suggesting the existence of …

There is a high incidence of metabolic syndrome among patients with primary aldosteronism
(PA), which has recently been associated with an unfavorable cardiometabolic profile …

Single gene mutations have been implicated in the pathogenesis of a form of diabetes
mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there …

Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …

Abstract Paired box gene 4 (PAX4) is a transcriptional modulator located on chromosome
7q32, and its expression is dysregulated in a variety of human cancers, suggesting that …