Pathophysiology of diabetes: An overview
MZ Banday, AS Sameer, S Nissar - Avicenna journal of …, 2020 - thieme-connect.com
Diabetes mellitus is a chronic heterogeneous metabolic disorder with complex
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …
pathogenesis. It is characterized by elevated blood glucose levels or hyperglycemia, which …
Genetic testing of maturity-onset diabetes of the young current status and future perspectives
P Firdous, K Nissar, S Ali, BA Ganai, U Shabir… - Frontiers in …, 2018 - frontiersin.org
Diabetes is a global epidemic problem growing exponentially in Asian countries posing a
serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a …
serious threat. Among diabetes, maturity-onset diabetes of the young (MODY) is a …
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci
Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
Abstract Type 1 diabetes (T1D) in children results from autoimmune destruction of
pancreatic beta cells, leading to insufficient production of insulin. A number of genetic …
pancreatic beta cells, leading to insufficient production of insulin. A number of genetic …
Monogenic diabetes: what it teaches us on the common forms of type 1 and type 2 diabetes
Y Yang, L Chan - Endocrine reviews, 2016 - academic.oup.com
To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
PAX4 Mutations in Thais with Maturity Onset Diabetes of the Young
N Plengvidhya, S Kooptiwut… - The Journal of …, 2007 - academic.oup.com
Context: Six maturity onset diabetes of the young (MODY) genes have been discovered to
date but account for a small proportion of MODY among Asians, suggesting the existence of …
date but account for a small proportion of MODY among Asians, suggesting the existence of …
Differential immunolocalization of estrogen receptor alpha and beta in rat ovary and uterus
H Hiroi, S Inoue, T Watanabe, W Goto… - Journal of …, 1999 - jme.bioscientifica.com
There is a high incidence of metabolic syndrome among patients with primary aldosteronism
(PA), which has recently been associated with an unfavorable cardiometabolic profile …
(PA), which has recently been associated with an unfavorable cardiometabolic profile …
[HTML][HTML] Genetics and pathophysiology of maturity-onset diabetes of the young (MODY): A Review of current trends
TO Yahaya, SB Ufuoma - Oman Medical Journal, 2020 - ncbi.nlm.nih.gov
Single gene mutations have been implicated in the pathogenesis of a form of diabetes
mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there …
mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there …
Pax4 in health and diabetes
J Ko, VA Fonseca, H Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …
Transcriptional control of PAX4-regulated miR-144/451 modulates metastasis by suppressing ADAMs expression
J Zhang, X Qin, Q Sun, H Guo, X Wu, F Xie, Q Xu… - Oncogene, 2015 - nature.com
Abstract Paired box gene 4 (PAX4) is a transcriptional modulator located on chromosome
7q32, and its expression is dysregulated in a variety of human cancers, suggesting that …
7q32, and its expression is dysregulated in a variety of human cancers, suggesting that …