[HTML][HTML] Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria
LW Thomas, M Ashcroft - Cellular and Molecular Life Sciences, 2019 - Springer
Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important
for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical …
for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical …
[HTML][HTML] Hypoxia in solid tumors: how low oxygenation impacts the “Six Rs” of radiotherapy
Radiotherapy is an important component of cancer treatment, with approximately 50% of all
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
cancer patients receiving radiation therapy during their course of illness. Nevertheless, solid …
[HTML][HTML] Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion
T Hao, J Yu, Z Wu, J Jiang, L Gong, B Wang… - Nature …, 2023 - nature.com
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative
phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade …
phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade …
Mitochondrial dynamics and mitophagy in lung disorders
Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …
physiological adaptations and cellular stress responses to the environment. Various …
[HTML][HTML] Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
Chronic mitochondrial stress associates with major neurodegenerative diseases.
Recovering stressed mitochondria constitutes a critical step of mitochondrial quality control …
Recovering stressed mitochondria constitutes a critical step of mitochondrial quality control …
[HTML][HTML] Oxidative phosphorylation in cancer cells
Evidence suggests that mitochondrial metabolism may play a key role in controlling cancer
cells life and proliferation. Recent evidence also indicates how the altered contribution of …
cells life and proliferation. Recent evidence also indicates how the altered contribution of …
Mitochondrial and energy metabolism‐related properties as novel indicators of lung cancer stem cells
XQ Ye, Q Li, GH Wang, FF Sun… - … journal of cancer, 2011 - Wiley Online Library
Energy metabolism is the foundation of survival for all organisms, and mitochondria are the
most important energy‐supplying organelles in eukaryotic cells. However, the mitochondrial …
most important energy‐supplying organelles in eukaryotic cells. However, the mitochondrial …
Hypoxic regulation of mitochondrial metabolism and mitophagy in nucleus pulposus cells is dependent on HIF‐1α–BNIP3 axis
Nucleus pulposus (NP) cells reside in an avascular and hypoxic microenvironment of the
intervertebral disc and are predominantly glycolytic due to robust HIF‐1 activity. It is …
intervertebral disc and are predominantly glycolytic due to robust HIF‐1 activity. It is …
Apoptotic cell death under hypoxia
A Sendoel, MO Hengartner - Physiology, 2014 - journals.physiology.org
Eukaryotic life depends largely on molecular oxygen. During evolution, ingenious
mechanisms have evolved that allow organisms to adapt when oxygen levels decrease …
mechanisms have evolved that allow organisms to adapt when oxygen levels decrease …
Hypoxia and energetic tumour metabolism
MC Brahimi-Horn, G Bellot, J Pouyssegur - Current opinion in genetics & …, 2011 - Elsevier
The hypoxia-inducible factor (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumour cells. This …
largely responsible for alterations in cell metabolism in hypoxic tumour cells. This …