Astrocytes are now emerging as key participants in many aspects of brain development,
function and disease. In particular, new evidence shows that astrocytes powerfully control …

Dendrite morphogenesis is a complex but well-orchestrated process and includes the
development of dendritic branches, forming characteristic dendrite arbors, and dendritic …

Astrocytes negatively impact neuronal development in many models of neurodevelopmental
disorders (NDs); however, how they do this, and if mechanisms are shared across disorders …

In this article, we first present a summary of the general assumptions about Down syndrome
(DS) still to be found in the literature. We go on to show how new research has modified …

Astrocytes comprise half of the cells in the brain. Although astrocytes have traditionally been
described as playing a supportive role for neurons, they have recently been recognized as …

Members of the Wnt signaling family are important mediators of numerous developmental
events, including activity-dependent dendrite development, but the pathways regulating …

The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …

Trisomy for human chromosome 21 (Hsa21) results in Down syndrome (DS). The finished
human genome sequence provides a thorough catalog of the genetic elements whose …

Intellectual disability (ID) is the unavoidable hallmark of Down syndrome (DS), with a heavy
impact on public health. Accumulating evidence shows that DS is characterized by …

Although dendrite arborization patterns are hallmarks of neuronal type and critical
determinants of neuronal function, how dendritic arbors take shape is still largely unknown …