The catalytic action of serine peptidases depends on the interplay of a nucleophile, a
general base and an acid. In the classic trypsin and subtilisin families this catalytic triad is …

Viruses are major pathogenic agents that can cause a variety of serious diseases in
humans, other animals, and plants. Due to their clinical and scientific importance, viruses …

Mutations in DJ-1, a protein of unknown function, were recently identified as the cause for an
autosomal recessive, early onset form of familial Parkinson's disease. Here we report that DJ …

Mutations in DJ-1 cause recessively transmitted early-onset Parkinson disease (PD), and
oxidative damage to DJ-1 has been associated with the pathogenesis of late-onset sporadic …

DPP-IV is a prolyl dipeptidase, cleaving the peptide bond after the penultimate proline
residue. It is an important drug target for the treatment of type II diabetes. DPP-IV is active as …

We identified small-molecule dimer disruptors that inhibit an essential dimeric protease of
human Kaposi's sarcoma–associated herpesvirus (KSHV) by screening an α-helical mimetic …

The obligate intracellular pathogen Chlamydia trachomatis is the most common cause of
sexually transmitted bacterial disease. It secretes a protease known as chlamydial …

FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense
mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic …

There exists a d-enantiomer of aspartic acid in lactic acid bacteria and several
hyperthermophilic archaea, which is biosynthesized from the l-enantiomer by aspartate …

Proteases regulate a plethora of biological processes. Because they irreversibly cleave
peptide bonds, the activity of proteases is strictly controlled. While there are many ways to …