Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent
neurodegenerative diseases, affecting millions and costing billions each year in the United …

BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and
characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β …

Alzheimer disease (AD) is the most common cause of dementia in older individuals (> 65
years) and has a long presymptomatic phase. Preventive therapies for AD are not yet …

Despite the enormity of the societal and health burdens caused by Alzheimer's disease
(AD), there have been no FDA approvals for new therapeutics for AD since 2003. This …

Abstract Chalcone [(E)-1, 3-diphenyl-2-propene-1-one], a small molecule with α, β
unsaturated carbonyl group is a precursor or component of many natural flavonoids and …

Abnormal accumulation of β-amyloid (Aβ) peptides is a culprit in Alzheimer's disease (AD);
blocking Aβ generation is therefore being explored as a logical approach for AD treatment …

The current study was undertaken to unveil the protective effects of Luteolin, a natural
flavonoid, against amyloid-beta (Aβ1–42)-induced neuroinflammation, amyloidogenesis …

Abstract Background Both Alzheimer's disease (AD) and type 2 diabetes (T2D) share
common pathological features including inflammation, insulin signaling alterations, or …

Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies.
It is extensively utilized as a nutraceutical food supplement all over the world due to its high …

Dense-core plaques, whose centers contain highly polymerized and compacted aggregates
of amyloid β peptides, are one of the two defining histopathological features of Alzheimer's …