Epigenome-wide association studies: current knowledge, strategies and recommendations
The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …
between genetic and environmental factors. The variability in risk and outcomes in these …
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
Image processing and analysis methods for the Adolescent Brain Cognitive Development Study
Abstract The Adolescent Brain Cognitive Development (ABCD) Study is an ongoing,
nationwide study of the effects of environmental influences on behavioral and brain …
nationwide study of the effects of environmental influences on behavioral and brain …
[HTML][HTML] Harmonization of large MRI datasets for the analysis of brain imaging patterns throughout the lifespan
As medical imaging enters its information era and presents rapidly increasing needs for big
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …
data analytics, robust pooling and harmonization of imaging data across diverse cohorts …
Harmonization of cortical thickness measurements across scanners and sites
With the proliferation of multi-site neuroimaging studies, there is a greater need for handling
non-biological variance introduced by differences in MRI scanners and acquisition …
non-biological variance introduced by differences in MRI scanners and acquisition …
Evaluation of brain-body health in individuals with common neuropsychiatric disorders
Importance Physical health and chronic medical comorbidities are underestimated,
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide …
Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years
Delineating the association of age and cortical thickness in healthy individuals is critical
given the association of cortical thickness with cognition and behavior. Previous research …
given the association of cortical thickness with cognition and behavior. Previous research …
The normative modeling framework for computational psychiatry
Normative modeling is an emerging and innovative framework for mapping individual
differences at the level of a single subject or observation in relation to a reference model. It …
differences at the level of a single subject or observation in relation to a reference model. It …
Statistical harmonization corrects site effects in functional connectivity measurements from multi‐site fMRI data
Acquiring resting‐state functional magnetic resonance imaging (fMRI) datasets at multiple
MRI scanners and clinical sites can improve statistical power and generalizability of results …
MRI scanners and clinical sites can improve statistical power and generalizability of results …
[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) …