Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi
There is no effective cure for Chagas disease, which is caused by infection with the
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …
arthropod-borne parasite, Trypanosoma cruzi. In the search for new drugs to treat Chagas …
Opportunities and challenges of RiPP-based therapeutics
IPM Pfeiffer, MP Schröder, S Mordhorst - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2024Ribosomally synthesised and post-translationally modified peptides
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …
Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response
EA Alpizar-Sosa, NRB Ithnin, W Wei… - PLoS Neglected …, 2022 - journals.plos.org
Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen
independent lines of Leishmania mexicana and one L. infantum line were selected for …
independent lines of Leishmania mexicana and one L. infantum line were selected for …
[HTML][HTML] Effects of a novel β–lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis
DO Dos Anjos, ESS Alves, VT Gonçalves… - International Journal for …, 2016 - Elsevier
Natural products comprise valuable sources for new antiparasitic drugs. Here we tested the
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …
effects of a novel β–lapachone derivative on Trypanosoma cruzi parasite survival and …
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning
LN Alberca, ML Sbaraglini, D Balcazar… - Journal of computer …, 2016 - Springer
Chagas disease is a parasitic infection caused by the protozoa Trypanosoma cruzi that
affects about 6 million people in Latin America. Despite its sanitary importance, there are …
affects about 6 million people in Latin America. Despite its sanitary importance, there are …
Nanomedicine for gene delivery and drug repurposing in the treatment of muscular dystrophies
I Andreana, M Repellin, F Carton, D Kryza, S Briançon… - Pharmaceutics, 2021 - mdpi.com
Muscular Dystrophies (MDs) are a group of rare inherited genetic muscular pathologies
encompassing a variety of clinical phenotypes, gene mutations and mechanisms of disease …
encompassing a variety of clinical phenotypes, gene mutations and mechanisms of disease …
Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi
C Reigada, EA Valera-Vera, M Sayé… - PLoS Neglected …, 2017 - journals.plos.org
Polyamines are essential compounds to all living organisms and in the specific case of
Trypanosoma cruzi, the causative agent of Chagas disease, they are exclusively obtained …
Trypanosoma cruzi, the causative agent of Chagas disease, they are exclusively obtained …
Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential
LV Carruthers, JC Munday, GU Ebiloma… - Molecular …, 2021 - Wiley Online Library
Trypanosoma congolense is a principal agent causing livestock trypanosomiasis in Africa,
costing developing economies billions of dollars and undermining food security. Only the …
costing developing economies billions of dollars and undermining food security. Only the …
[HTML][HTML] Enfermedad de Chagas: realidad de una patología frecuente en Santander, Colombia
JM Palmezano Díaz, LK Plazas Rey, KE Rivera Castillo… - Médicas Uis, 2015 - scielo.org.co
Introducción: la tripanosomiasis americana o enfermedad de Chagas es una de las
parasitosis transmitidas por insectos hematófagos de mayor importancia epidemiológica en …
parasitosis transmitidas por insectos hematófagos de mayor importancia epidemiológica en …
Targets and patented drugs for chemotherapy of Chagas disease in the last 15 years-period
V G. Duschak - Recent patents on anti-infective drug discovery, 2016 - benthamdirect.com
Background: The American trypanosomiasis, Chagas disease, is a parasitic infection
typically spread by triatomine vectors affecting millions of people all over Latin America …
typically spread by triatomine vectors affecting millions of people all over Latin America …