Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to
understand the mechanisms that specify germ cells is a central challenge in developmental …

'The development of a multicellular organism from a single egg cell requires both the
determination of many cell types and the organization of these cells into an elaborate pattern …

This weighty book was written with the objective of providing a summary of the practice of
Drosophila genetics and biology. The emphasis is on experimental methods, the author's …

The baculovirus P35 protein functions to prevent apoptotic death of infected cells. We have
expressed P35 in the developing embryo and eye of the fly Drosophila melanogaster. P35 …

Germline stem cells play a pivotal role in gametogenesis; yet little is known about how they
are formed, how they divide to self-renew, and how these processes are genetically …

The signals directing primordial germ cell (PGC) migration in vertebrates are largely
unknown. We demonstrate that sdf-1 mRNA is expressed in locations where PGCs are …

The oskar gene directs germ plasm assembly and controls the number of germ cell
precursors formed at the posterior pole of the Drosophila embryo. Mislocalization of oskar …

Summary oskar is one of seven Drosophila maternal-effect genes that are necessary for
germline and abdomen formation. We have cloned oskar and show that oskar RNA is …

Identification and manipulation of the germ line are important to the study of model
organisms. Although zebrafish has recently emerged as a model for vertebrate …

Determinants of pole cells, which are precursors of the germ line, are provided maternally
and are localized to the posterior pole of the Drosophila egg, as are polar granules. It has …