These genes represent novel asthma susceptibility genes. Variations in CHI3L1 and CHIA
have been associated with asthma risk. Polymorphisms in CHIT1 have not yet been …

Background Gaucher disease (GD) is the most common lysosomal storage disorder (LSD).
Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide …

Chitinases, enzymes that cleave chitin's chain to low molecular weight chitooligomers, are
widely distributed in nature. Mammalian chitinases belong to the 18-glycosyl-hydrolase …

Objectives Neurochemical markers of amyotrophic lateral sclerosis (ALS) that reflect
underlying disease mechanisms might help in diagnosis, staging and prediction of outcome …

Rationale: Serum chitinases may be novel biomarkers of airway inflammation and
remodeling, but less is known about factors regulating their levels. Objectives: To examine …

TGF-β1 is a critical mediator of tissue fibrosis in health and disease whose effects are
augmented by chitinase 1 (CHIT1). However, the mechanisms that CHIT1 uses to regulate …

Chitotriosidase (ChT) is an enzyme that is selectively activated in tissue macrophage. This
property of ChT makes it a potential marker for many disease process and prognostication …

Gaucher disease (GD) is an autosomal recessive disease which if undiagnosed or
diagnosed late results in devastating complications. Because of the heterozygous nature of …

The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role
in human immune response. ChT activity is increased in atherosclerosis in association to the …

Introduction Chitotriosidase (CTO) is a human chitinolytic enzyme secreted by activated
macrophages and polymorphonuclear neutrophils. Albeit not specific for sarcoidosis, it is …