Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely
contributing to tumor immune evasion. The deregulation mainly arises from the potentiated …

Vasculogenic mimicry (VM) is a brand‐new tumour vascular paradigm independent of
angiogenesis that describes the specific capacity of aggressive cancer cells to form vessel …

Vascular endothelial growth factor-2 (VEGFR-2) is considered one of the most important
factors in tumor angiogenesis, and consequently a number of anticancer therapeutics have …

Novel antiangiogenic cancer therapies, particularly agents that block vascular endothelial
growth factor (VEGF) signalling, have improved outcomes in patients with cancers and are …

Malignant gliomas are the most common malignant primary brain tumors and one of the
most challenging forms of cancers to treat. Despite advances in conventional treatment, the …

Polycystic ovary syndrome (PCOS) is the most prevalent endocrine pathology among
women in reproductive age. Its main symptoms are oligo or amenorrhea, hyperandrogenism …

The early stages of angiogenesis can be divided into three steps: endothelial cell
proliferation, migration, and tube formation. Vascular endothelial growth factor (VEGF) is …

Drug resistance imposes severe limitations to the efficacy of targeted therapy in BRAF-
mutated metastatic melanoma. Although this issue has been mitigated by the development …

Multitargeting kinase inhibitors recently proved to be a profitable approach for conquering
cancer proliferation. The current study represents the design and synthesis of new …

Angiogenesis is one of the hallmarks of cancer. Several studies have shown that vascular
endothelium growth factor (VEGF) plays a leading role in angiogenesis progression …