Cancer along with cardiovascular disease are the main causes of death in the industrialised
countries around the World. Conventional cancer treatments are losing their therapeutic …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

Mitogen-dependent progression through the first gap phase (G1) and initiation of DNA
synthesis (S phase) during the mammalian cell division cycle are cooperatively regulated by …

Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …

Inheritance requires genome duplication, reproduction of chromatin and its epigenetic
information, mechanisms to ensure genome integrity, and faithful transmission of the …

Biologic machines need brakes, and the nature and fidelity of their operation cannot be
unraveled without some prior understanding of how accelerators work. The discoveD] of …

To maintain genome function and stability, DNA sequence and its organization into
chromatin must be duplicated during cell division. Understanding how entire chromosomes …

Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism
as a component of the replication and repair machinery. This toroidal-shaped protein …

The association of cdk4 with D-type cyclins to form functional kinase complexes is
comparatively inefficient. This has led to the suggestion that assembly might be a regulated …

Mutations are rare events, occurring spontaneously at a frequency of 1 per 109-1010 base
pairs per cell division. 1, 2 Nucleotide misincorporation during DNA synthesis yields …