Chromatin 'readers' are central interpreters of the epigenome that facilitate cell-specific
transcriptional programs and are therapeutic targets in cancer and inflammation. The …

Simple Summary This review provides an in depth analysis of the role of bromodomain-
containing proteins in cancer development. As readers of acetylated lysine on nucleosomal …

Background Plant homeodomain (PHD) fingers are central “readers” of histone post-
translational modifications (PTMs) with> 100 PHD finger-containing proteins encoded by the …

Epigenetic “readers” that recognize defined posttranslational modifications on histones have
become desirable therapeutic targets for cancer and inflammation. SP140 is one such …

Inflammatory bowel disease (IBD) is driven by host genetics and environmental factors,
including commensal microorganisms. Speckled Protein 140 (SP140) is an immune …

SP140 locus has been associated with multiple sclerosis (MS) as well as other autoimmune
diseases by genome-wide association studies (GWAS). The causal variant of these …

Alchemically derived free energies are artifacted when the perturbed moiety has a nonzero
net charge. The source of the artifacts lies in the effective treatment of the electrostatic …

Background Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional
splicing process not only controlled by RNA-binding splicing factors, but also mediated by …

We have shown previously that Sp100 (a component of the ND10 nuclear body) represses
transcription, replication and establishment of incoming human papillomavirus (HPV) DNA …

ABSTRACT Sp100 (speckled protein 100 kDa) is a constituent component of nuclear
structure PML (promyelocytic leukemia) bodies, playing important roles in mediating intrinsic …