Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a
global pandemic, and cases continue to rise. Most infected individuals experience mildly …

Immunological memory is a composite of lasting antibody titers maintained by plasma cells
in conjunction with memory T and B cells. Memory B cells are a critical reservoir for plasma …

The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

T‐cell exhaustion has been extensively researched, compared with B‐cell exhaustion and
NK‐cell exhaustion, which have received considerably less attention; and there is less of a …

Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …

NF-κB signaling is essential to an effective innate and adaptive immune response. Many
immune-specific functional and developmental outcomes depend in large on NF-κB. The …

Lung-resident memory B cells (lung-BRMs) differentiate into plasma cells after reinfection,
providing enhanced pulmonary protection. Here, we investigated the determinants of lung …

Poxviruses (PXVs) are mostly known for the variola virus, being the cause of smallpox;
however, re-emerging PXVs have also shown a great capacity to develop outbreaks of pox …