Macrophages are important immune cells in innate immunity, and have remarkable
heterogeneity and polarization. Under pathological conditions, in addition to the resident …

Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Hepatic fibrosis is a common pathological process involving persistent liver injury with
various etiologies and subsequent inflammatory responses that occur in chronic liver …

At present chronic liver disease (CLD), the third commonest cause of premature death in the
United Kingdom is detected late, when interventions are ineffective, resulting in …

Fibrosis is the major determinant of morbidity and mortality in patients with nonalcoholic
steatohepatitis (NASH) but has no approved pharmacotherapy in part because of …

The liver is not only the main metabolic site of exogenous compounds and drugs, but also
an important immune organ in the human body. When a large number of nonself substances …

Hepatic fibrosis is characterized by the pathological accumulation of extracellular matrix
(ECM) in the liver resulting from the persistent liver injury and wound-healing reaction …

Macrophages are crucial components of the immune system and play a critical role in the
initial defense against pathogens. They are highly heterogeneous and plastic and can be …

The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Purpose of review Advancing our understanding of the mechanisms that underlie NASH
pathogenesis. Recent findings Recent findings on NASH pathogenesis have expanded our …