The presence of atypical cytoskeletal dynamics, structures, and associated morphologies is
a common theme uniting numerous diseases and developmental disorders. In particular …

It is well established that neurodegenerative diseases known as tauopathies are
characterized by the presence of filamentous forms of phosphorylated tau protein inside …

The main approach used in the current therapy of mucopolysaccharidosis (MPS) is to
reduce the levels of glycosaminoglycans (GAGs) in cells, the deposits considered to be the …

Abstract Aims Hirano bodies (HBs) are eosinophilic pathological structures with two
morphological phenotypes commonly found in the hippocampal CA1 region in Alzheimer's …

Blood dynamically and richly supplies the cerebral tissue via microvessels invested in pia
matter perforating the cerebral substance. Arteries penetrating the cerebral substance derive …

There is a growing number of aging populations that are more prone to the prevalence of
neuropathological disorders. Two major diseases that show a late onset of the symptoms …

摘要肌动蛋白聚合在细胞过程中发挥着关键作用, 包括细胞分裂, 发育, 形态发生,
运动和极性建立等重要过程. 肌动蛋白聚合异常可引发心血管疾病, 神经系统疾病和癌症等多种 …

Over the years, cancer research has focused on different strategies to discover drugs and
therapies to treat the metastatic stage of cancer. This stage depends upon the type, and the …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the
loss of upper and lower motor neurons in the motor cortex, brain stem, and the anterior horn …

Cytoskeletal proteins, which are unique to eukaryotic cells, form a three-dimensional niche
filling the cytoplasm. It is quite essential for a myriad of cellular processes in higher …