New therapeutic strategies are direly needed in the fight against cancer. Over the last
decade, several tumor ablation strategies have emerged as stand-alone or combination …

Alternative splicing (AS) is a pivotal posttranscriptional regulatory mechanism that is
involved in embryonic development. However, the roles of AS in specific developmental …

Immunocompromised mice are commonly utilized to study pancreatic cancer and other
malignancies. The ability to xenograft tumors in either subcutaneous or orthotopic locations …

Zygotic genome activation (ZGA) is initiated once the genome chromatin state is organized
in the newly formed zygote. Telomeres are specialized chromatin structures at the ends of …

Alternative splicing (AS) of mRNA precursors allows the synthesis of multiple mRNAs from a
single primary transcript, significantly expanding the information content and regulatory …

Context Maternal-effect genes (MEGs) play a critical role in modulating both cellular and
molecular biology events in preimplantation embryonic development. Damage-specific DNA …

Mammalian early embryonic development is a precise and complex biological process that
includes a series of morphological (eg cleavage or compaction), cytological (eg polarisation …