The role of NMDA receptors in Alzheimer's disease

J Liu, L Chang, Y Song, H Li, Y Wu - Frontiers in neuroscience, 2019 - frontiersin.org
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Cognitive training for people with mild to moderate dementia

A Bahar‐Fuchs, A Martyr, AMY Goh… - Cochrane Database …, 2019 - cochranelibrary.com
Background Cognitive impairment, a defining feature of dementia, plays an important role in
the compromised functional independence that characterises the condition. Cognitive …

A review on Alzheimer's disease pathophysiology and its management: an update

A Kumar, A Singh - Pharmacological reports, 2015 - Elsevier
Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

[HTML][HTML] Drug treatments in Alzheimer's disease

R Briggs, SP Kennelly, D O'Neill - Clinical medicine, 2016 - Elsevier
Despite the significant public health issue that it poses, only five medical treatments have
been approved for Alzheimer's disease (AD) and these act to control symptoms rather than …

Alzheimer's disease; a review of the pathophysiological basis and therapeutic interventions

A Abeysinghe, R Deshapriya, C Udawatte - Life sciences, 2020 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder and is identified as the most
common cause for dementia. Despite huge global economic burden and the impact on the …

Drugs in clinical trials for Alzheimer's disease: the major trends

SO Bachurin, EV Bovina… - Medicinal research …, 2017 - Wiley Online Library
Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

[HTML][HTML] Calcium signaling in Alzheimer's disease & therapies

BCK Tong, AJ Wu, M Li, KH Cheung - Biochimica et Biophysica Acta (BBA) …, 2018 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and is characterized by the
accumulation of amyloid (Aβ) plaques and neurofibrillary tangles in the brain. Much attention …

Impact of HMGB1, RAGE, and TLR4 in Alzheimer's disease (AD): from risk factors to therapeutic targeting

YN Paudel, E Angelopoulou, C Piperi, I Othman… - Cells, 2020 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …

Current and future treatments for Alzheimer's disease

KG Yiannopoulou… - Therapeutic advances in …, 2013 - journals.sagepub.com
Alzheimer's dementia (AD) is increasingly being recognized as one of the most important
medical and social problems in older people in industrialized and non-industrialized …

Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials

G Grosso, A Pajak, S Marventano, S Castellano… - PloS one, 2014 - journals.plos.org
Background Despite omega-3 polyunsaturated fatty acids (PUFA) supplementation in
depressed patients have been suggested to improve depressive symptomatology, previous …