Background Recent advances are enabling delivery of precision genomic medicine to
cancer clinics. While the majority of approaches profile panels of selected genes or hotspot …

Oncogenic KRAS mutations are absent in approximately 10% of patients with metastatic
pancreatic ductal adenocarcinoma (mPDAC) and may represent a subgroup of mPDAC with …

Over a decade of sequencing-based genomics research has unveiled a diverse somatic
mutation landscape across patients with pancreatic ductal adenocarcinoma (PDAC), and the …

Advancements in genomic and precision medicine have changed the way oncology clinical
trials are designed. Compared to the traditional single tumour-based trial, master protocols …

Tumor mutational burden (TMB) is gaining attention as a biomarker for responses to immune
checkpoint inhibitors in cancer patients. In this study, we evaluated the status of TMB in …

(1) Background: Precision oncology has the potential to improve patient health and
wellbeing through targeted prevention and treatment. Owing to uncertain clinical and …

Cancer is a complex disease with a large financial and healthcare burden on society. One
hallmark of the disease is the uncontrolled growth and proliferation of malignant cells. Unlike …

Synthetic glucocorticoids (GCs), such as prednisone, prednisolone, and dexamethasone,
are used to manage many parts of the continuum of care needed by veterinary oncology …

10Epigenetic Targeting of Cancer Page 1 10Epigenetic Targeting of Cancer JACOB CAWLEY
1,2* 1Case Western Reserve University, Cleveland, Ohio, USA; 2Ethos Discovery, San Diego …

Genome sequencing has transformed our understanding of human genetic diseases in
recent years, not least of which is Cancer. Among the genetic abnormalities commonly …