Standardizing designed and emergent quantitative features in microphysiological systems
DM Nahon, R Moerkens, H Aydogmus… - Nature biomedical …, 2024 - nature.com
Microphysiological systems (MPSs) are cellular models that replicate aspects of organ and
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
tissue functions in vitro. In contrast with conventional cell cultures, MPSs often provide …
Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models
In vitro modelling the complex (patho‐) physiological conditions of the heart is a major
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …
challenge in cardiovascular research. In recent years, methods based on three‐dimensional …
Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure …
Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …
Engineering biomaterials and approaches for mechanical stretching of cells in three dimensions
W Zhang, G Huang, F Xu - Frontiers in bioengineering and …, 2020 - frontiersin.org
Mechanical stretch is widely experienced by cells of different tissues in the human body and
plays critical roles in regulating their behaviors. Numerous studies have been devoted to …
plays critical roles in regulating their behaviors. Numerous studies have been devoted to …
Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue
LR Sewanan, S Shen… - American Journal of …, 2021 - journals.physiology.org
Comprehensive functional characterization of cardiac tissue includes investigation of length
and load dependence. Such measurements have been slow to develop in engineered heart …
and load dependence. Such measurements have been slow to develop in engineered heart …
[HTML][HTML] Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics
Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …
significant global health challenge. Consequently, the development of innovative …
[HTML][HTML] Dynamic mechanobiology of cardiac cells and tissues: Current status and future perspective
Mechanical forces impact cardiac cells and tissues over their entire lifespan, from
development to growth and eventually to pathophysiology. However, the mechanobiological …
development to growth and eventually to pathophysiology. However, the mechanobiological …
Tissue engineering techniques for induced pluripotent stem cell derived three-dimensional cardiac constructs
T Salem, Z Frankman, JM Churko - Tissue Engineering Part B …, 2022 - liebertpub.com
Recent developments in applied developmental physiology have provided well-defined
methodologies for producing human stem cell derived cardiomyocytes. The cardiomyocytes …
methodologies for producing human stem cell derived cardiomyocytes. The cardiomyocytes …
Engineering biomaterials to guide heart cells for matured cardiac tissue
The extracellular matrix (ECM) is needed to maintain the structural integrity of tissues and to
mediate cellular dynamics. Its main components are fibrous proteins and …
mediate cellular dynamics. Its main components are fibrous proteins and …
Interplay of genotype and substrate stiffness in driving the hypertrophic cardiomyopathy phenotype in iPSC-micro-heart muscle arrays
Introduction In clinical and animal studies, Hypertrophic Cardiomyopathy (HCM) shares
many similarities with non-inherited cardiac hypertrophy induced by pressure overload …
many similarities with non-inherited cardiac hypertrophy induced by pressure overload …